Bicosome® - Intelligent Skin Delivery



Double encapsulation to protect actives

 

Designed to deliver active ingredients to specific skin layers

 

Targeted delivery without damaging the skin

This page gives an overview of the bicosome products in general.  Commercial Bicosome products are listed below.

Technology overview


Bicosome is a proprietary skin delivery technology focused on target delivery of active ingredients to specfic skin layers.

 

Bicosome is composed of a combination of two lipid assemblies. The first lipid assembly is forming so-called ‘smart discs’ that carry the active ingredients. A collection of smart discs is then enclosed by the second lipid assembly: an external lipid vesicle. The two lipid assemblies combined form a double encapsulation of the active ingredient.

 

Cryo-TEM image give a good visual overview of the Bicosome structure. Both the outer lipid assembly and the lipid structures that for the smart discs are clearly visible.

These cryo-TEM images show the resemblance of the Bicosome structure to the structure of the skin's natural lamelar bodies.

 

Upon application, the outer vesicle fuses with the skin's surface. The smart discs are thereby delivered to the skin. The discs then pass through the narrow inter-cellular spaces of the Stratum Corneum and start to penetrate into the skin.

When the targeted skin layer is reached, the smart discs become part of the skin's lipid structure and the active ingredient is released.

 

Smart discs are designed to reach specific skin layers and are thus able to deliver active ingredients to the skin layer where they need to be. Fluorescence microscopy images of skin samples treated with different Bicosome prototypes demonstrate the penetration of the smart discs to the targeted skin layers: Stratum Corneum, Epidermis and Dermis. The Bicosome prototypes used in these tests contain fluorescein as to visualize skin penetration.

Application and uses


Bicosome is a technology platform for targeted delivery of actives. The currently available commercial products can be used in a range of products and applications for different purposes:

 

Skin care: Targeted delivery of actives for skin repair, deep sun repair, anti-oxidant activity, skin whitening and sebum control/oil control

Color cosmetics: Targeted delivery of actives for skin repair, deep sun repair, anti-oxidant activity, skin whitening and sebum control/oil control

Lip products: Targeted delivery of actives for skin repair, soothing and firmness

Commercial Bicosome® products, benefits and claims

 

The Bicosome technology platform and the individual commercial products have the following product benefits and allow for the following finished product claims:

 

Bicosome® technology in general:

  • Protecting active ingredients for long-term stability
  • Targeted delivery of actives to the skin layer where they are needed
  • Lower active ingredient dosage for same effect
  • Targeted delivery without damaging the microstructure of the skin
  • Restoring the skin’s lipid structure

 

Bicosome® FS*:

  • Biomimetic filler that restores the skin’s lipid structure
  • Reduces water loss and improves skin elasticity
  • 7 days long-lasting effect

 

Bicotene® Complex*: (Click for more info)

  • Epidermal delivery of pro-retinol
  • Deep skin protection from UV, blue light, visible light and IR damage
  • Prevents the main causes of photoaging
  • Click here for more info...

 

Bicowhite®: (Click for more info)

  • Multi-target delivery of five whitening actives
  • Effectively blocks the main processes involved in dark spot formation
  • High specificity for hyper-pigmented areas

 

Bicomide®:

  • Sebum control at the source
  • Oil control by tackling sebum production
  • Preventive care for acne-prone skin

 

Click here to submit a sample request

 

*The standard product form for Bicosome is a water-based liquid. For Bicosome FS and Bicotene Complex a special lyophylized version is available for ease of use in an oil phase

Formulation guidelines


The following formulation guidelines will help in successfully using the Bicosome products in formulations:

 

Liquid (water-based) Bicosome® products:

  • Post-add Bicosome® to the O/W emulsion upon cooling down
  • Recommended dosage: 1 - 3%
  • Optimum pH range: 4 – 8
  • Preferred processing temperature: <50˚C

 

Lyophylized Bicosome® products (available for Bicosome® FS and Bicotene® Complex):

  • Post-add Bicosome® to the W/O emulsion upon cooling down
  • Recommended dosage: 0.2 – 0.6%
  • Preferred processing temperature: <50˚C

 

Dos and Don’ts:

  • Do not dissolve Bicosome® in any solvents
  • Avoid harsh surfactants
  • Do not use in formulations with alcohol content of >15%
  • Avoid strong oxidants, such as peroxides

 

Global compliance


All Bicosome products are globally compliant (including China) for use as cosmetic ingredient

INCI


Bicosome® FS:  Aqua, Lecithin, Hydrogenated Phosphatidylcholine, Lysolecithin, Sodium Benzoate,

Citric Acid, Potassium Sorbate, Phytic Acid, Tocopherol, Beta-Sitosterol, Squalene

 

Bicosome® FS Lyophylized: Lecithin, Hydrogenated Phosphatidylcholine, Lysolecithin, Phenethyl Alcohol, Caprylyl Glycol, Caprylhydroxamic Acid, Tocopheryl Acetate, Disodium EDTA, Aqua

 

Bicotene® Complex:  Aqua, Lecithin, Hydrogenated Phosphatidylcholine, Lysolecithin, Glycine Soja Oil,

Sodium Benzoate, Citric Acid, Potassium Sorbate, Phytic Acid, Tocopherol, Beta-Sitosterol, Squalene,

Daucus Carota Sativa Root Extract, Beta-Carotene

 

Bicotene® Complex - Lyophylized: Lecithin, Hydrogenated Phosphatidylcholine, Lysolecithin, Glycine Soja Oil, Tocopheryl Acetate, Phenethyl Alcohol, Caprylyl Glycol, Caprylhydroxamic Acid, Sodium phytate, Daucus Carota Sativa Root Extract, Beta-Carotene, Tocopherol, Aqua

 

Bicowhite®: Aqua, Lecithin, Potassium Azeloyl Diglycinate, Lysolecithin, Niacidamide, 3-0-Ethyl Ascorbic Acid, Phenethyl Alcohol, Bisabolol, Caprylhydroxamic Acid, Tocopheryl Acetate, Phytic Acid, Caprylyl Glycol

 

Bicomide®: Aqua, Lecithin, Niacinamide, Lysolecithin, Phenethyl Alcohol, Caprylhydroxamic Acid, Tocopheryl Acetate, Caprylyl Glycol, Phytic Acid

 

Click here to submit a sample request

 

The Bicosome® products are developed and manufactured by Bicosome company (www.bicosome.com). Ultra is the supplier of the Bicosome® products in parts of the US and Canada.

Ultra Chemical Inc.

2 Bridge Avenue Suite 631

Red Bank, NJ 07701

USA

 

Ultra Chemical BV

Zuidplein 36 - 1077

XV Amsterdam

The Netherlands

 

Cryo-TEM image give a good visual overview of the Bicosome structure. Both the outer lipid assembly and the lipid structures that for the smart discs are clearly visible.

Upon application, the outer vesicle fuses with the skin's surface. The smart discs are thereby delivered to the skin. The discs then pass through the narrow inter-cellular spaces of the Stratum Corneum and start to penetrate into the skin.